6 research outputs found

    Physics of the HL-LHC, and Perspectives at the HE-LHC

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    Combined measurements of Higgs boson couplings in proton- proton collisions at v s=13TeV

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    Combined measurements of the production and decay rates of the Higgs boson, as well as its couplings to vector bosons and fermions, are presented. The analysis uses the LHC proton-proton collision data set recorded with the CMS detector in 2016 at fb-1. The combination is based on analyses targeting the five main Higgs boson production mechanisms (gluon fusion, vector boson fusion, and associated production with a W or Z boson, or a top quark-antiquark pair) and the following decay modes: H, ZZ, WW, , bb, and . Searches for invisible Higgs boson decays are also considered. The best-fit ratio of the signal yield to the standard model expectation is measured to be =1.17 +/- 0.10, assuming a Higgs boson mass of 125.09. Additional results are given for various assumptions on the scaling behavior of the production and decay modes, including generic parametrizations based on ratios of cross sections and branching fractions or couplings. The results are compatible with the standard model predictions in all parametrizations considered. In addition, constraints are placed on various two Higgs doublet models.Peer reviewe

    Measurement of prompt D-0 and D-0 meson azimuthal anisotropy and search for strong electric fields in PbPb collisions at root S-NN=5.02 TeV

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    Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome

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    none99siBackground Neurofilament light chain (NfL) represents a promising biomarker for axonal injury. We present the first exploratory study on serum NfL in patients with a clinically isolated syndrome (CIS) and healthy controls. Methods We investigated serum NfL levels in 100 patients with CIS with a short conversion interval to clinically definite multiple sclerosis (MS) (fast converters (FC), median (IQR) conversion time: 110 days (79-139)); 98 patients with non-converting CIS (non-converters (NC), follow-up: 6.5 years (5.3-7.9)); and 92 healthy controls. Results NfL levels were higher in FC (24.1 pg/mL (13.5-51.8)) and NC (19.3 pg/mL (13.6-35.2)) than in healthy controls (7.9 pg/mL (5.6-17.2)) (OR=5.85; 95% CI 2.63 to 13.02; p=1.5×10-5 and OR=7.03; 95% CI 2.85 to 17.34; p=2.3×10-5, respectively). When grouping FC and NC, increased serum NfL concentration was also associated with increasing numbers of T2 hyperintense MRI lesions (OR=2.36; 95% CI 1.21 to 4.59; p=0.011), gadolinium-enhancing lesions (OR=2.69; 95% CI 1.13 to 6.41; p=0.026) and higher disability scores (OR=2.54; 95% CI 1.21 to 5.31; p=0.013) at CIS diagnosis. Conclusions If replicated in future studies, serum NfL may represent a reliable and easily accessible biomarker of early axonal damage in CIS and MS.restrictedDisanto G1, Adiutori R2, Dobson R2, Martinelli V3, Dalla Costa G3, Runia T4, Evdoshenko E5, Thouvenot E6, Trojano M7, Norgren N8, Teunissen C9, Kappos L10, Giovannoni G2, Kuhle J, Bianchi L, Topping J, Bestwick JP, Meier UC, , Lazareva N, Iaffaldano P, Direnzo V, Khademi M, Piehl F, Comabella M, Sombekke M, Killestein J, Hegen H, Rauch S, D'Alfonso S, Alvarez-Cermeño JC, KleinovĂĄ P, HorĂĄkovĂĄ D, Roesler R, Lauda F, Llufriu S, Avsar T, Uygunoglu U, Altintas A, Saip S, Menge T, Rajda C, Bergamaschi R, Moll N, Khalil M, Marignier R, Dujmovic I, Larsson H, Malmestrom C, Scarpini E, Fenoglio C, Wergeland S, Laroni A, Annibali V, Romano S, MartĂ­nez AD, Carra A, Salvetti M, Uccelli A, Torkildsen Ø, Myhr KM, Galimberti D, Rejdak K, Lycke J, Frederiksen JL, Drulovic J, Confavreux C, Brassat D, Enzinger C, Fuchs S, Bosca I, Pelletier J, Picard C, Colombo E, Franciotta D, Derfuss T, Lindberg RL, Yaldizli Ö, VĂ©csei L, Kieseier BC, Hartung HP, Villoslada P, Siva A, Saiz A, Tumani H, HavrdovĂĄ E, Villar LM, Leone M, Barizzone N, Deisenhammer F, Montalban X, TintorĂ© M, Olsson T, Lehmann S, Castelnovo G, Lapin S, Hintzen R, Furlan R, Comi G, Ramagopalan SV.Disanto, G1; Adiutori, R2; Dobson, R2; Martinelli, V3; Dalla Costa, G3; Runia, T4; Evdoshenko, E5; Thouvenot, E6; Trojano, M7; Norgren, N8; Teunissen, C9; Kappos, L10; Giovannoni, G2; Kuhle, J; Bianchi, L; Topping, J; Bestwick, Jp; Meier, Uc; Lazareva, N; Iaffaldano, P; Direnzo, V; Khademi, M; Piehl, F; Comabella, M; Sombekke, M; Killestein, J; Hegen, H; Rauch, S; D'Alfonso, S; Alvarez-Cermeño, Jc; KleinovĂĄ, P; HorĂĄkovĂĄ, D; Roesler, R; Lauda, F; Llufriu, S; Avsar, T; Uygunoglu, U; Altintas, A; Saip, S; Menge, T; Rajda, C; Bergamaschi, R; Moll, N; Khalil, M; Marignier, R; Dujmovic, I; Larsson, H; Malmestrom, C; Scarpini, E; Fenoglio, C; Wergeland, S; Laroni, A; Annibali, V; Romano, S; MartĂ­nez, Ad; Carra, A; Salvetti, M; Uccelli, A; Torkildsen, Ø; Myhr, Km; Galimberti, D; Rejdak, K; Lycke, J; Frederiksen, Jl; Drulovic, J; Confavreux, C; Brassat, D; Enzinger, C; Fuchs, S; Bosca, I; Pelletier, J; Picard, C; Colombo, E; Franciotta, D; Derfuss, T; Lindberg, Rl; Yaldizli, Ö; VĂ©csei, L; Kieseier, Bc; Hartung, Hp; Villoslada, P; Siva, A; Saiz, A; Tumani, H; HavrdovĂĄ, E; Villar, Lm; Leone, M; Barizzone, N; Deisenhammer, F; Montalban, X; TintorĂ©, M; Olsson, T; Lehmann, S; Castelnovo, G; Lapin, S; Hintzen, R; Furlan, R; Comi, G; Ramagopalan, Sv

    Study of quark and gluon jet substructure in Z plus jet and dijet events from pp collisions

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    Measurements of jet substructure describing the composition of quark- and gluon-initiated jets are presented. Proton-proton (pp) collision data at √ s = 13 TeV collected with the CMS detector are used, corresponding to an integrated luminosity of 35.9 fb−1 . Generalized angularities are measured that characterize the jet substructure and distinguish quark- and gluon-initiated jets. These observables are sensitive to the distributions of transverse momenta and angular distances within a jet. The analysis is performed using a data sample of dijet events enriched in gluon-initiated jets, and, for the first time, a Z+jet event sample enriched in quark-initiated jets. The observables are measured in bins of jet transverse momentum, and as a function of the jet radius parameter. Each measurement is repeated applying a “soft drop” grooming procedure that removes soft and large angle radiation from the jet. Using these measurements, the ability of various models to describe jet substructure is assessed, showing a clear need for improvements in Monte Carlo generators
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